We are very happy to welcome as a keynote speaker at our Status Meeting 2024:
Max-Planck-Institut für Kohlenforschung, Organometallic Chemistry
Title: “A New Reactivity Paradigm: trans-Hydrogenation, gem-Hydrogenation, and trans-Hydrometalation of Alkynes”
This lecture intends to showcase some unconventional ways of harnessing the reactivity of alkynes via highly selective metal-catalyzed transformations. After a review of our work in the area of triple bond metathesis [1], some unorthodox addition reactions to internal alkynes will be discussed, including metal catalyzed trans-hydrogenation, trans-hydroboration, trans-hydrostannation, trans-hydroalkynylation and trans-chloroalkynylation, which have little precedent in the literature, if any [2].
Even more perplexing is the ability to transfer both H-atoms of H2 to one and the same C-atom of a triple bond with concomitant formation of a discrete metal carbene at the adjacent position (“gem-hydrogenation”) [2]. This entirely new reactivity mode unlocks numerous opportunities for organic synthesis and organometallic chemistry alike, which we have started to explore.
The underlying mechanisms will be discussed in some detail; selected applications to target-oriented synthesis are meant to illustrate the current state of development.
Reviews: [1] A. Fürstner, J. Am. Chem. Soc. 2021, 143, 15538. [2] A. Fürstner, J. Am. Chem. Soc. 2019, 141, 11.
The CRC cordially invites all who are interested to the lecture.
