Collaborative Research Center 1333

Molecular Heterogeneous Catalysis
in Confined Geometries

B03 – Asymmetric nucleophilic addition

Prof. Dr. Sabine Laschat
Prof. Dr. Sabine Laschat
University of Stuttgart
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Zarfishan Dilruba
Zarfishan Dilruba
University of Stuttgart
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The aim is to understand and control chirality transfer, catalytic activity and mechanism of chiral diene-metal complexes covalently tethered inside a mesoporous material by using the asymmetric Rh-catalyzed 1,4-addition of boronic acids to enones as a benchmark system. The confinement effects resulting from a) the steric confinement of the catalyst and substrate in a pore of certain size and geometry, b) the polarity gradient between the inner pore surface and the catalyst in the centre and c) solvent interactions with inner pore surface and the ligand sphere will be examined by various experimental and theoretical methods.

Asymmetric 1,4-addition with Rh diene catalysts in mesopores. The chiral diene ligand is attached to a spacer that is anchored to the pore wall through a triazole moiety (highligted in red)
Asymmetric 1,4-addition with Rh diene catalysts in mesopores. The chiral diene ligand is attached to a spacer that is anchored to the pore wall through a triazole moiety (highligted in red)
X-ray crystal structures of the investigated tetrahydropentalene ligand scaffold (top) and the respective Rh diene complex (bottom)
X-ray crystal structures of the investigated tetrahydropentalene ligand scaffold (top) and the respective Rh diene complex (bottom)
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